Advancing LINE-1 Reverse Transcriptase Inhibitors in Autoimmune & Neurodegenerative Diseases
Time: 9:00 am
day: Day 2
Details:
- Repeat elements like LINE-1 make up most of our DNA, and their expression is silenced in healthy cells
- When aberrantly expressed in disease, LINE-1 reverse transcriptase (RT) drives interferon signaling and “sterile inflammation”
- LINE-1 RT inhibitors inhibit tissue interferon signaling and inflammation. They target large patient populations and have the potential to be non-immune suppressive therapies
