A Robust Computational Approach to Unraveling the Role of Highly Repetitive Elements in Human Health & Disease
Time: 2:30 pm
day: Day 2
Details:
- Highly repetitive elements comprise > 50% of the human genome, while canonical protein-coding genes comprise only ~2%
- Naive approaches to the quantification of the expression of these elements fail to address their unique challenges, resulting in estimates that obscure their association with disease
- ROME’s custom ML algorithms and curated databases enable highly accurate locus level quantification of expression and activity of these repetitive elements, supporting their relevance in disease
